红细胞和白细胞等血细胞在我们的血液中流动。在癌症患者的血液中,极少量的癌细胞可与血细胞混合。世界各地的研究人员正在关注这些所谓循环肿瘤细胞 (CTC) 的癌细胞,它们与癌症转移有关。
为了帮助从形态学细胞信息中发现血液中的 CTC,在滨松光子学株式会社,我们正在研发能够使单个细胞内部结构可视化的 3D 成像流式细胞仪。
定量相位显微镜 (QPM) 是一种使用光干涉的显微镜,可用于观察活细胞的形态,无需染色。QPM 能够测量纳米级的形态特征,并有潜力量化活细胞在药物治疗或/和分化之前和之后的细微变化。我们正在开发带有 QPM 的图像细胞计数系统,以便为先进的生物医学研究(如再生医学)做出贡献。
日本女性的乳腺癌发病率一直在增加。用于诊断和监测治疗反应的测量技术对于提高乳腺癌患者的生活质量 (QOL) 非常重要。近红外光谱法 (NIRS) 是一种无创测量技术,可以量化生物组织中的吸收和散射系数、血红蛋白浓度和组织氧饱和度。用于 NIRS 测量的光的波长范围为 700 nm 至 1100 nm,相比其他波长的光,具有更高的透射率。NIRS 预期用于检测因乳腺癌生长或缩小而引起的参数变化。光学乳腺成像是一种专为乳腺测量设计的 NIRS 系统,将提供对乳腺癌的早期检测和更容易的监测。
中性粒细胞是一种白细胞,主要负责先天免疫。它们保护我们的身体免受细菌等外来入侵物的侵袭。我们开发了一种方法,可以同时监测先天免疫应答期间白细胞内部和周围发生的事件。因此,基于细胞的测定抗氧化/抗炎/免疫刺激活性的方法已被确立为评估食品成分功能的方法。我们现在正在开发一种新型系统,即使在少量 (3 μl) 全血中也能轻松准确地测量中性粒细胞激活。该系统可以检测与炎症相关的中性粒细胞过度激活,并评估体内氧化剂和抗氧化剂之间的平衡,因此有望用作健康(症状前疾病)检查标志物。
基于我们多年来积累的 PET 技术,我们在世界上首次成功开发出了用于测量线粒体功能的 PET 探针。我们不仅使用我们独特的 PET 探针促进生物功能研究,还以合同研究的方式开展药物评估研究。
(我们遵守研究伦理,在进行动物实验时考虑动物福利。)
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