光学波前调制是一种自由操纵光波前(相位的空间分布)的技术。该技术是实现精确激光处理、全息三维处理、利用自适应光学的眼底成像、操纵分子马达等微小物体、生物样品内部的三维超分辨率显微测量、脉冲波形控制等用途中不可或缺的元素。为了进一步实现先进的调制,我们正在研究高速、高精度的传感技术,而且我们认为将这两种技术相结合可以获得新的用途和知识。作为这种先进的光波前控制的一个具体示例,我们已开发一项专有技术,即硅上液晶 - 空间光调制器 (LCOS - SLM) 和智能视觉传感器 (IVS) 作为关键器件。我们正在推动有关技术产业应用和医疗设备应用的基础研究。
光学扭矩扳手是一种利用称为“光旋涡”的光学力对物质施加旋转力的技术,已知这种光学力具有特殊性质。先进的光学技术是获得光旋涡所必需的,我们事实上已经建立足以生成光旋涡的高级技术。我们的高精度光学扭矩扳手能够控制单个分子的动力,并且/或者精确地测量分子产生的皮牛顿级小力。
我们专注于点扩散函数 (PSF) 的理论计算和 LCOS-SLM 动态控制,该函数解释了光学系统对点光源的响应特性。我们需要高精度光学技术和相位调制,通过推进技术开发并将其应用于显微镜,我们分别或同时成功实现了多点、像差校正、多焦和景深延拓。我们还将应用于超分辨率显微镜和非线性显微镜,为进一步提高显微镜观察技术做出贡献。
通过使用可以精确控制光波前的 SLM,可以实现像差校正等各种功能。我们计划将 SLM 提供的波前控制整合到双光子激发荧光显微镜系统中。这将使我们能够以高精度和简单的方式观察生物组织的深层部分。我们正在与滨松大学医学院合作,对这种高精度显微镜系统进行基础和应用研究。未来,我们的目标是在与各大学合作的同时,为医疗和生物研究做出贡献。
具有飞秒和皮秒速度的超短脉冲激光对于激光加工和细胞的高灵敏度测量非常有用,因为脉冲激光可以减少对目标的热损伤。然而,减少效应在很大程度上取决于脉冲形状,因为它们会诱发非线性过程。因此,需要一种技术能够完全控制脉冲串的脉冲波形形状和间隔。我们开发了一种高精度调制脉冲光所含光谱相位和强度的方法,旨在创造一种新的具有高控制度的波形整形技术。此外,通过与大阪大学合作推动波形测量方法的研究,我们正在努力进一步提高波形控制的精度。
太赫兹 (THz) 波是波段介于光波和无线电波之间的电磁波。太赫兹波拥有巨大潜力,因为它兼具光波和无线电波的特性。太赫兹波也有望在未来用于 6G 通信。 为了探索这一领域,我们研发了各种设备和系统,例如用于太赫兹波的硅棱镜波片和紧凑易用的 THz-ATR(太赫兹波衰减全反射)光谱仪。我们预见到太赫兹波未来的用途将会不断扩展,因此正在开发新的太赫兹设备,并研究利用太赫兹光谱仪和太赫兹成像技术进行药物、食品和材料分析的用途。
拉曼散射光谱是一种分子振动光谱,它提供分子结构信息,因此可以进行定性和定量分析。尽管拉曼光谱仪由于拉曼信号本身的弱点而不适用于痕量定量,但金属纳米结构的表面增强效应使得拉曼光谱仪能够在单分子水平上检测分析物。我们开发了基于银离子化学还原的 SERS 活性银纳米结构的原位制备技术。这项技术可用于需要快速性的场景,如环境、法医分析和威胁检测。
复杂的光谱具有测量样品中包括的分子的许多信息。通常,应用各种光谱分析方法(例如,主成分和回归分析)从光谱中提取可用信息。我们公司研发了采用深度学习技术的新型光谱分析方法,适用于高精度光谱鉴别、真实性评估和混合比定量分析等多种用途。
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